Blar i forfatter "Berge, Gerd"

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    • Anticancer activity of bovine lactoferricin and a cytolytic 9-mer peptide : from milk to cancer vaccine? 

      Berge, Gerd (Doctoral thesis; Doktorgradsavhandling, 2009-12-09)
      Cationic antimicrobial peptides (CAPs) are found in many diverse species playing a part in the innate immune system. CAPs are important as antimicrobial agents in most organisms, being able to kill a wide range of bacteria as well as fungi, enveloped viruses and protozoa. Certain CAPs also exhibit direct cytotoxic activity against many different types of human cancer cells. Bovine lactoferricin ...

    • Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315 

      Camilio, Ketil André; Berge, Gerd; Ravuri, Chandra Sekhar; Rekdal, Øystein; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death 

      von Hofsten, Susannah; Norvoll Magnussen, Synnøve; Ausbacher, Dominik; Paulsen, Marianne Hagensen; Bayer, Annette; Strøm, Morten B.; Berge, Gerd (Conference object; Konferansebidrag, 2020-03)
      The marine natural product mimic MHP 88 is a novel synthetic molecule based on unique structures found in molecules from an arctic marine bryozoan. Initial studies showed that MHP88 kills cancer cells efficiently, but is not hemolytic. In this study, we look closer at the mode of death induced by MHP88 in oral cancer (HSC-3) and lymphoma (Ramos) cell lines. Immunogenic cell death (ICD) is a mode of ...

    • The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines 

      von Hofsten, Susannah; Paulsen, Marianne Hagensen; Magnussen, Synnøve; Ausbacher, Dominik; Kranz, Mathias; Bayer, Annette; Strøm, Morten Bøhmer; Berge, Gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-16)
      Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce immunogenic cell death can be administered as intratumoral injections with the aim to activate anti-tumor immune responses by causing the release of tumor antigens as well as damage-associated molecular patterns (DAMPs) from dying cancer cells. In ...

    • The pH-Responsive Liposomes—The Effect of PEGylation on Release Kinetics and Cellular Uptake in Glioblastoma Cells 

      Rustad, Eirik André Lindeløff; von Hofsten, Susannah; Kumar, Robin; Lænsman, Eirik Abrahamsen; Berge, Gerd; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)
      Nanomedicine has been, to a certain degree, a success story in the development of superior anticancer therapies. However, there are tumors that remain a huge challenge for nanoformulations, for instance, brain tumors such as glioblastoma, the most common and aggressive brain tumor. To utilize the fact that such tumors are characterized by an acidic extracellular environment, we selected pH-responsive ...